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Without adequate treatment, hypertension can lead to serious complications such as heart attack, stroke, kidney damage, and vascular diseases. A key pillar of the therapy in hypertension, the long-term, continuous use of antihypertensive drugs in the Form of tablets. These drugs aim to reduce the systolic and the diastolic blood pressure to a healthy range of below 140/90 mmHg (or, according to current guidelines, in some cases even below 130/80 mmHg). Common drug classes to the continuous application For the permanent treatment of various groups of active substances are available, the use of different physiological mechanisms: ACE inhibitors (Angiotensin‑converting enzyme inhibitors), such as Enalapril or Ramipril: The formation of Angiotensin II inhibit, a potent blood vessel narrowing substance. Lead vessels to a relaxation of the blood, and thus to a decrease of the peripheral resistance. AT1‑receptor blockers (Sartans), such as Losartan or Valsartan: Blocking the effect of Angiotensin II to its receptors. Have a similar effect as ACE inhibitors, often with better compatibility (less cough). Beta-blockers, such as Metoprolol or Bisoprolol: To reduce the heart rate and the force of heart muscle contraction. Particularly in patients with cardiac arrhythmias or heart attack of Use. Calcium channel blockers, such as amlodipine or Verapamil: Prevent the influx of Calcium into the smooth muscle of the blood vessel walls. Lead to vasodilatation and, consequently, to the reduction in blood pressure. Diuretics (water tablets) such as hydrochlorothiazide and indapamide: Increase the excretion of water and salt through the kidneys. The blood to reduce volume and blood pressure. Principles of continuous therapy The most important success factors in the treatment of hypertension, regular and long-term use of the prescribed tablets — often long-life. The following aspects are of Central importance: Regularity: The tablets should be taken at the same time, a constant drug concentration in the body to maintain. Compliance: The willingness of the patient, the medication exactly as prescribed to take, is essential. Low Compliance level leads to uncontrolled blood pressure and an increased risk of complications. Customization: The choice of the active substance and the dose is selected individually, taking into account the age, comorbidities (e.g., Diabetes, kidney disease) and possible side effects. Combination therapy: In many patients, the combination of two or more drugs from different classes is required in order to achieve the Target goal. Such combinations may be administered in a tablet (fixed dose combination) or as separate tablets. Conclusion The continuous use of blood pressure-lowering tablets is a proven and effective method for the control of arterial hypertension. 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Degree (140-159/90-99 mmHg) examine the patterning Commission: the stability of the blood pressure values; the Presence of risk factors (e.g. Obesity, Diabetes); possible organ damage (heart, kidneys, eyes, background); the effectiveness of the treatment. What is a deferral is possible? A delay (e.g., 6-12 months) may be granted if: the blood is not stabilized pressure medication; further studies are necessary; lifestyle Modification (diet, exercise) is sought. Your path to a valid deferral: Thorough medical examination, you Can drop your blood pressure over a longer period of time to document. All documents: blood pressure diary, findings, medication list. Confirmation by a specialist: A cardiologist or Internist should assess their health status and to confirm in writing. Template for patterning: Submit all the documents in a timely manner to the competent authority. Nothing is left to chance! 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High blood pressure (arterial hypertension) is a widespread disease, which can eventually lead to serious complications such as heart attack, stroke, or kidney failure be liable. For the treatment of various groups of Drugs are used, some of which, however, as a side effect of a dry cough can trigger. Drugs that can cause cough ACE inhibitors (Angiotensin‑converting enzyme inhibitor) This drug group is one of the most common triggers of a drug-induced cough. Among the well-known representatives: Lisinopril Enalapril Ramipril Captopril The cough occurs in 10-20% of patients with ACE‑inhibitor use, and is often dry, lovely and durable. It can occur at any time during the therapy, but usually within the first few weeks or months. Pathomechanism: ACE inhibitors inhibit the enzyme for the removal of substances such as Bradykinin is responsible. The resulting increased concentration of Bradykinin in the respiratory tract, irritating the nerve endings, triggering the cough reflex. ARB (Angiotensin II receptor blockers) This group includes substances like: Losartan Valsartan Candesartan Compared to ACE‑inhibitors, ARB cause significantly less cough (&lt;5% of the cases), thus, are considered as an Alternative in patients who respond to ACE inhibitors, with cough. Differential diagnosis and Management In the event of a persistent cough during an anti-hypertensive therapy, the following steps should be taken: To the exclusion of other possible causes: Diseases of the respiratory system (e.g. Asthma, COPD) Infections of the respiratory tract Heart failure with pulmonary edema Reflux disease Medication review: Determination of whether a ACE is taken inhibitor Analysis of other possible drugs interactions Therapy adjustment: In cases in which the connection between ACE inhibitors and cough: Discontinuation of the ACE Inhibitor Switching to an ARB or other antihypertensive agent (e.g., calcium channel blockers, thiazide diuretic) Observation: The cough subsides, usually within 1-4 weeks after Discontinuation of the drug. Conclusion A dry cough may occur as a known side‑effect, in particular when taking ACE inhibitors. This reaction by the pharmacological mechanism of action of these classes of compounds is explained. In cases of suspected drug-related cough is a careful differential diagnosis is necessary, followed by a targeted adjustment of hypertension therapy. The change to the ARB, or other antihypertensive agents often allows the continuation of an effective reduction in blood pressure without coughing load. Note: Prior to any Change in medication, a doctor's consultation is mandatory. Independent Discontinuation of Hypertension drugs can be dangerous. Would you like me to make a certain section in more detail, or for more information about additional?